Arnold E. Ruoho,Abdol R. Hajipour,Uyen B. Chu,Dominique A. Fontanilla
申请号：
US13707418
公开号：
US08946302B2
申请日:
2012.12.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.
