GUY HERMANS,HANS GUEHRING,MARIE -ANGE BUYSE,RALF GUENTHER,ROLAND KELLNER,SVEN LINDEMANN
申请号：
BR112019024333
公开号：
BR112019024333A2
申请日:
2018.06.04
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to immunoglobulins that bind adamts5 and more particularly to polypeptides, which comprise or essentially consist of one or more of said immunoglobulins (also referred to herein as "immunoglobulin (s) of the invention" and "polypeptides of the invention" ", respectively). the invention also relates to constructs comprising said immunoglobulins, such as unique immunoglobulin variable domains (isvds) or polypeptides as well as nucleic acids encoding said immunoglobulins or polypeptides (also referred to herein as "nucleic acids of the invention"； methods for preparing said immunoglobulins, polypeptides and constructs； host cells expressing or capable of expressing said immunoglobulins or polypeptides； compositions, and in particular pharmaceutical compositions, comprising said immunoglobulins, polypeptides, constructs, nucleic acids and / or host cells； and the uses of immunoglobulins, polypeptides, constructs, nucleic acids, host cells and / or compositions, in particular for prophylactic and / or therapeutic purposes, such as the prophylactic and / or therapeutic purposes mentioned in this document. modalities, advantage teachings and applications of the invention will become clear from the further description in this document.a presente invenção refere-se a imunoglobulinas que ligam adamts5 e mais em particular a polipeptídeos, que compreendem ou essencialmente consistem em uma ou mais das referidas imunoglobulinas (também referidas no presente documento como "imunoglobulina(s) da invenção" e "polipeptídeos da invenção", respectivamente). a invenção também se refere aos construtos compreendendo as referidas imunoglobulinas, tais como domínios variáveis únicos de imunoglobulina (isvds) ou polipeptídeos assim como ácidos nucleicos que codificam as referidas imunoglobulinas ou polipeptídeos (também referidos no presente documento como "ácidos nucleicos da invenção"； aos métodos para preparar as referidas imunoglobulinas, polipeptídeos e c
