Disclosed is a method of treating a subject with cancer, the method comprising the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 μmol/m2 to 315 μmol/m2 and a bis(thiohydrazide amide) compound in an amount between about 1473 μmol/m2 and about 1722 μmol/m2.