Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.本文描述化合物、包括此類化合物之醫藥組合物及藥劑以及使用此類化合物調節瞬時受器電位類香草素1受體(TRPV1)活性之方法。