Herein are disclosed protected optical fiber terminations for use in the treatment of renal and biliary calculi. The protected optical fiber termination including a ferrule affixed to the optical fiber that provides the termination of the optical fiber with protection from contact with saline and/or biological fluids. The optical fiber termination can include open or closed ferrules. The open ferrules providing a means for maintaining a bubble, e.g., a Moses bubble on the termination the closed ferrules providing a calumniated focus on the renal or biliary calculi.
