ß-內醯胺酶抑制劑化合物农业专利-农业学术服务平台

发明人:: HUYNH, HOAN, KHAI,胡英　红安　凯,胡英　紅安　凱,COMITA-PREVOIR, JANELLE,卡蒙塔　派沃尔　珍奈尔,卡蒙塔　派沃爾　珍奈爾,CHEN, BRENDAN,陈　布兰登,陳　布蘭登,DURAND-REVILLE, THOMAS,杜兰　瑞弗尔　汤玛士,杜蘭　瑞弗爾　湯瑪士,GULER, SATENIG,古勒　塞特尼,XIONG, HUI,宋惠,D,胡英红安凯,胡英紅安凱,卡蒙塔派沃尔珍奈尔,卡蒙塔派沃爾珍奈爾,陈布兰登,陳布蘭登,杜兰瑞弗尔汤玛士,杜蘭瑞弗爾湯瑪士,古勒塞特尼

摘要：: The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R2, R3 and R4 are described herein.本發明係關於ß-內醯胺酶抑制劑化合物。該等化合物及其醫藥學上可接受之鹽適合與ß-內醯胺抗生素組合或單獨用於治療細菌感染，包括由耐藥生物體(包括多重耐藥生物體)所引起之感染。本發明包括式(Ia)之化合物：或其醫藥學上可接受之鹽，其中R1、R2、R3及R4之值描述於本文中。