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PREPARATION POUR TRANSFUSION
专利权人:
OTSUKA PHARMACEUTICAL FACTORY; INC.
发明人:
TANI, SEIJI,MITSUMOTO, YASUHIRO
申请号:
CA2819212
公开号:
CA2819212C
申请日:
2011.11.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
An object of the present invention is to provide aninfusion preparation in which the Maillard reaction between anamino acid and a reducing sugar does not occur during storage andthe size of fat particles in the fat emulsion does not increaseduring storage, and in which various types of vitamins can beincorporated in a stable manner, in spite of the fact that it isa two-chamber infusion preparation. Furthermore, even if only oneof the infusions (of the infusion preparation) is administered,the patient is unlikely to develop hyperkalemia, vascular pain,or phlebitis. The present invention provides an infusionpreparation containing two chambers separated by a partition thatcan be communicably opened, wherein a first chamber contains afirst-chamber infusion containing a sugar and a fat emulsion, asecond chamber contains a second-chamber infusion containing anamino acid and an electrolyte, the first-chamber infusion issubstantially free of potassium, and has a relative osmoticpressure of 2.0 to 3.0, the second-chamber infusion has apotassium concentration of 40 mEq/L or less and a relativeosmotic pressure of 2.5 to 3.5, and a mixture of the first- andsecond-chamber infusions has a potassium concentration of 16mEq/L or more as measured upon communicably opening the partition.
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