#$%^&*AU2015372456A120161013.pdf#####ABSTRACT An artificially synthesized insect-resistant protein, biological materials associated therewith, and use thereof are disclosed. The protein provided in the present invention is designated as MRPOO1 protein, and is a protein of Al) or A2): Al) a protein having an amino 5 acid sequence as shown in SEQ ID No.6; and A2) a protein having insect resistance derived from Al) by substituting, and/or deleting, and/or adding one or more amino acid residues in the amino acid sequence of the protein of Al). In the present invention, it is confirmed through experiments that the MRPOO1 protein and biological materials associated therewith have resistance to plant bug, and are useful in the preparation of biological ant-insect agent 10 containing the protein, and in the cultivation of insect-resistant transgenic cotton, fruits, tea, rice, vegetables and other crops, thereby reducing the application of pesticides and alleviating the environmental pollution, and thus being of great economic value and broad application prospect. 34 7924744_1 (GHMatters) P103530.AU