DRY POWDER FOR INHALATION FORMULATION COMPRISING SALMETEROL XINAFOATE, FLUTICASONE PROPIONATE AND TIOTROPIUM BROMIDE, AND METHOD FOR PREPARING THE SAME
KIM, KYEONG SOO,김경수,LEE, DEOK KYU,이덕규,KIM, DONG HO,김동호,KIM, YONG IL,김용일,PARK, JAE HYUN,박재현,WOO, JONG SOO,우종수
申请号：
KR1020120063665
公开号：
KR1020130140358A
申请日:
2012.06.14
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention provides dry powder comprising salmeterol xinafoate, fluticasone propionate, tiotropium bromide, and carrier as medical activating components and an inhalation formulation including the same. When inhaling, the three medical activating components of the dry powder inhalation formulation, which has excellent content uniformity and less variation in dynamic particle distribution about velocity change, fully reach a target area, so that the formulation is useful for prevention and treatment of respiratory diseases , particularly asthma and chronic obstructiv lung disease (COPD). [Reference numerals] (AA) Dynamic grain size distribution test of salmeterol；(BB) Sum of stage 1-5；(CC) Example 1；(DD) Example 1 (Handihaler)；(EE) Example 5；(FF) Comparative example 2；(GG) Comparative example 3본 발명은 약리활성성분으로서 살메테롤 지나포산염, 플루티카손 프로피오네이트 및 티오트로피움 브로마이드, 및 담체를 포함하는 건조 분말； 및 이를 포함하는 흡입 제형으로서, 상기 건조 분말 흡입 제형은 흡입시 상기 세 가지 약리활성성분이 목표 부위로 충분히 도달하고, 함량균일성이 우수할 뿐 아니라 유속변화에 다른 동적입자분포의 변화가 적어, 호흡기 질환, 특히 천식 및 만성 폐쇄성 폐질환(COPD)의 예방 또는 치료에 유용하다.
