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MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY
专利权人:
Alain COMMERCON;Claudia FROMOND;Fabienne PARKER;Hervé BOUCHARD;Ingrid SASSOON;Vincent MIKOL;Daniel TAVARES
发明人:
Hervé BOUCHARD,Alain COMMERCON,Claudia FROMOND,Vincent MIKOL,Fabienne PARKER,Ingrid SASSOON,Daniel TAVARES
申请号:
US13434363
公开号:
US20120276124A1
申请日:
2012.03.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to a compound of formula (I):wherein:ALK is a (C1-C6)alkylene group;X1 et X2 are each independently one of the following groups: —CH═CH—, —CO—, —CONR—, —NRCO—, —COO—, —OCO—, —OCONR—, —NRCOO—, —NRCONR′—, —NR—, —S(O)n (n=0, 1 or 2) or —O—;R and R′ are independently H or a (C1-C6)alkyl group;i is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10;j is an integer corresponding to 1 when X2 is —CH═CH— and 2 when X2 is not —CH═CH—;Zb is a simple bond, —O— or —NH— and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal.
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