COMPOSE AMIDE HETEROCYCLIQUE AROMATIQUE CONTENANT DE L'AZOTE BICYCLIQUE

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专利权人:

ASTELLAS PHARMA INC.

发明人:

OHNUKI, KEI,AZAMI, HIDENORI,SAWADA, YUKI,SHIN, TAKASHI,KURAMOTO, KAZUYUKI,KIKUCHI, SHIGETOSHI,SAITO, TOMOYUKI,HAMAGUCHI, HISAO,NAGASHIMA, TAKEYUKI

申请号：

CA2914982

公开号：

CA2914982A1

申请日:

2014.06.09

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

This invention relates to a bicyclic nitrogen-containing aromatic heterocyclic amide compound of formula (I), or a salt thereof, which has excellent Complex 1 inhibitory effect and AMPK activating effect, and which is useful as a therapeutic drug for breast cancer. This compound has a cell growth inhibitory effect on a human PIK3CA mutation-positive breast cancer cell line not expressing MCT4 and on a human breast cancer cell line not expressing MCT4 and not having a PIK3CA mutation, and exhibits antitumor action in human PIK3CA mutation-positive breast cancer cell line MDA-MB-453 cell tumor-bearing mice not expressing MCT4.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/