A prosthetic spacer (3000) for implanting at the native mitral valve region comprising: a spacer body (3004) configured for placement within the native mitral valve, a pair of ventricular anchors (3008, 3010) coupled to and disposed outside of the spacer body (3004) and a pair of atrial anchors (3012, 3014) coupled to and disposed outside of the spacer body (3004).