#$%^&*AU2018204877B220191107.pdf#####ABSTRACT A system for persistently increasing the overall diameter and lumen diameter of a peripheral vein is provided. The system is configured to increase the speed of blood in the peripheral vein. The system comprises a pump configured to pump blood, a first conduit fluidly coupled to the pump and configured to make a fluid connection with a donating vessel and convey blood from the donating vessel to the pump, a second conduit fluidly coupled to the pump and configured to make a fluid connection to the peripheral vein and convey blood from the pump to the peripheral vein, and a control unit in communication with the pump and configured to cause the pump to pump blood in a manner such that a wall shear stress in the peripheral vein is greater than or equal to 0.76 Pa until a persistent increase in the overall diameter of the peripheral vein occurs. The pump and the first and second conduits form a pumpconduit assembly. The control unit and the pump-conduit assembly are configured to pump blood in a manner such that a mean pulse pressure in the second conduit fluidly connected to the peripheral vein is less than 20 mmHg. Also provided is use of the system for increasing the overall diameter lumen of a peripheral vein of a patient. A method of using a system for persistently increasing the overall diameter and lumen diameter of a peripheral vein in a human patient is also provided. A method of using a system for creating an arteriovenous fistula, an arteriovenous graft, or a bypass graft in a human patient is also provided.
