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PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
专利权人:
AMGEN INC.
发明人:
BIO, Matthew,CAILLE, Sebastien,COCHRAN, Brian,FANG, Yuanqing,FOX, Brian,LUCAS, Brian,MCGEE, Lawrence,VOUNATSOS, Filisaty,WIEDEMANN, Sean,WORTMAN, Sarah
申请号:
TN2015000521
公开号:
TN2015000521A1
申请日:
2014.06.09
申请国别(地区):
TN
年份:
2017
代理人:
摘要:
the present invention provides processes for making 2 - ((3r, 5r.6s) - 5 - (3) - chlorophenyl) - 5 - (4-chlorophenyl) - 1 - ((s) - 1 - (isopropylsulfonyl) - 3 - methylbutan - 2 - yl) - 3 - methyl - 2 - oxopiperidin - 3 - yl) acetic acid as well as intermediates and processes for making the intermediayour. also provided are crystalline forms of the compound and the interrnediates.The present invention provides processes for making 2-((3R,5R,6S)-5-(3-5 chlorophenyl)-6-( 4-chlorophenyl)-1-( (S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the interrnediates.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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