Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.本文揭示包括源於個體腫瘤之新抗原編碼核酸序列的黑猩猩腺病毒載體。亦揭示與該等載體相關之核苷酸、細胞及方法,包括該等載體作為疫苗之用途。