There is provided an isolated antibody that binds to the extracellular domain of PDGFRβ and neutralizes PDGFRβ activity, said antibody comprising a VL domain comprising CDRs LCDR1, LCDR2, and LCDR3 and a VH domain comprising CDRs HCDR1, HCDR2, and HCDR3, wherein:LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443；LCDR2 has the amino acid sequence shown in SEQ ID NO: 434；LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444；HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445；HCDR2 has the amino acid sequence shown in SEQ ID NO: 437；HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442
