Chunlei Li,Yanhui Li,Min Liang,Caixia Wang,Yajuan Wang,Shixia Wang,Dongjian Chen,Yongfeng Li
申请号：
US16668754
公开号：
US20200060982A1
申请日:
2019.10.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Purified therapeutic nanoparticles are provided herein. Such nanoparticles comprise an active pharmaceutical ingredient and human serum albumin, wherein the weight ratio of human serum albumin to the active ingredient in the therapeutic nanoparticles is from 0.01:1 to 1:1, and wherein the nanoparticles are substantially free of free human serum albumin that is not incorporated in the nanoparticles. The present disclosure also provides pharmaceutical compositions that comprise the purified therapeutic nanoparticles and are also substantially free of free human serum albumin. Methods for preparing and using the purified therapeutic nanoparticles and compositions thereof are also provided.
