Robert Edward Babine,Shu Hui Chen,Ivan Collado-Cano,Maria Cristina Garcia Paredes,John Irvin Glass,Ling Jin,Jason Eric Lamar,Raymond Samuel Parker, III,Nancy June Snyder,Xicheng David Sun,Deqi Guo,Yvo
申请号：
US14306778
公开号：
US20140294763A1
申请日:
2014.06.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors； intermediates thereto； their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
