The present invention provides a kind of venom that is suitable as and stings into the treatment method of patients first-line treatment scheme and/or antivenin supplemental treatment regimens,Pharmaceutical composition,System and kit,Use at least one active constituent,In some cases,At least two active constituents,In some other cases,No more than two kinds of active components,The active constituent is selected from selectivity secretion PLA2 inhibitor(SPLA2 or PLA2 inhibitor),Metal protease inhibitors,Serpin,Antitoxic serum,One or more acetylcholinesterase inhibitors or the nAChR agonists matched with mAChR antagonists,Nmda receptor antagonist and invasin inhibitor,It is preferred that in poisonous insect,As snake or invertebrate venom bruising are fashionable,It is no more than in about 1 hour usually after venom is stung,Or it is used in about 6 hours,Antivenin is used with or without during entire treatment as adjuvant treatment.