ANTIBODY, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, CELL, COMPOSITION, MIXTURE, USE OF A CHEMICAL ANTIBODY OR A FRAGMENT OF THE SAME OR A FRAGMENT OF THE SAME AND / OR A COMPOSITION AND / OR A FUNCTION PART OR A MIXTURE, METHODS FOR PREPARING A PHARMACEUTICAL COMPOSITION OR MIXTURE, TO PREVENT, TREAT OR RELIEVE THE EFFECTS OF DISEASES, DISORDERS OR CONDITIONS, DIAGNOSIS OF A DISEASE OR CONDITION, FOR DETERMINING PLAN CARGINES A FABRIC AND / OR BODY FLUIDS, TO DISAGGUE PRE-FORMED BETA-AMYLOID FIBERS, AND TO PREVENT ABETA-INDUCED NEURON DEGRADATION, DISEASE AND DIAGNOSTIC TEST KITS AND CONVEIA C
ANDREA PFEIFER,MARIA PIHLGREN,ANDREAS MUHS,RYAN WATTS
申请号：
BRPI0714713
公开号：
BRPI0714713A2
申请日:
2007.07.13
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The invention provides an artificial hybrid antibody comprising two different heavy/light chain pairs and two different binding sites, or active fragment thereof, wherein a first heavy/light chain pair binds beta-amyloid. The invention also provides a composition comprising the artificial hybrid antibody or active fragment thereof, and the composition for use in a method of treating or alleviating one or more effects of amyloidosis. The invention further provides a cell comprising two different nucleic acid molecules encoding a humanized antibody or epitope-binding fragment thereof that binds to beta-amyloid and method of producing a humanized antibody or epitope-binding fragment thereof that binds to beta-amyloid.
