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АНТИ-Axl АНТИТЕЛА И ИХ ПРИМЕНЕНИЕ
专利权人:
ИНСЕРМ (ЭНСТИТЮ НАСЬОНАЛЬ ДЕ ЛЯ САНТЭ Э ДЕ ЛЯ РЕШЕРШ МЕДИКАЛЬ)
发明人:
РОБЕР Брюно,ФОВЕЛЬ Бенедикт,ШЕВ Гвенаэль,ЯЗРИ Азиз,ЛАРБУРЕ Кристель,ЛЕКОНЕ Вилем,ШАРД Тьерри,ЛАРОК Кристиан,ПЕЛЕГРЕН Андре
申请号:
RU2014101707
公开号:
RU2014101707A
申请日:
2012.06.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A monoclonal antibody specific for Axl, comprising a heavy chain variable region comprising SEQ ID NO: 2 in the H-CDR1, SEQ ID NO: 3 in the H-CDR2, and SEQ ID NO: 4 in H-CDR3 and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1, SEQ ID NO: 7 in the L-CDR2 and SEQ ID NO: 8 in the L-CDR3.2. The monoclonal antibody of claim 1, wherein the variable region of the antibody heavy chain has the amino acid sequence shown in SEQ ID NO: 1.3. The monoclonal antibody of claim 1, wherein the variable region of the light chain of said antibody has the amino acid sequence shown in SEQ ID NO: 5.4. The monoclonal antibody of claim 2, wherein the heavy chain variable region of said antibody has the amino acid sequence shown in SEQ ID NO: 1 and a light chain variable region has the amino acid sequence shown in SEQ ID NO: 5.5. The monoclonal antibody of claim 4 which is a chimeric antibody, preferably a chimeric antibody mouse / chelovek.6. The monoclonal antibody of claim 1 which is a humanized antitelom.7. The monoclonal antibody of claim 1 which binds to the extracellular domain of Axl in the amino acid sequence shown in SEQ ID NO: 9 and the amino acid sequence shown in SEQ ID NO: 10.8. A fragment of a monoclonal antibody according to any one of claims. 1-7, which is selected from the group consisting of Fv, Fab, F (ab ) 2, Fab, dsFv, scFv, sc (Fv) 2 and diatel.9. The nucleic acid sequence encoding the heavy chain or light chain of a monoclonal antibody according to any one pp.1-7.10. A vector comprising the nucleic acid of p.9.11. A host cell containing a nucleic sour1. Моноклональное антитело, специфичное к Axl, содержащее вариабельную область тяжелой цепи, содержащую SEQ ID NO: 2 в области H-CDR1, SEQ ID NO: 3 в области H-CDR2, и SEQ ID NO: 4 в области H-CDR3 и вариабельную область легкой цепи, содержащую SEQ ID NO: 6 в области L-CDR1, SEQ ID NO: 7 в области L-CDR2 и SEQ ID NO: 8 в области L-CDR3.2. Моноклональное антитело по п.1, в котором вариабельная облас
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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