DÉGRADATION DE LA KINASE 8 CYCLINE-DÉPENDANTE (CDK8) PAR CONJUGAISON D'INHIBITEURS DE CDK8 AVEC UN LIGAND DE TYPE LIGASE E3 ET LEURS PROCÉDÉS D'UTILISATION
GRAY, Nathanael,ZHANG, Tinghu,OLSON, Calla M.,LIANG, Yanke,KWIATKOWSKI, Nicholas
申请号：
EP17786757
公开号：
EP3445764A4
申请日:
2017.04.21
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8.
