An applicator for applying a staple (1) for end-to-end vascular grafts to an end zone (2) of a body duct, comprises: a nose-piece (6) configured to be inserted into the end zone (2) of the body duct and positioned along a longitudinal axis (X) a first fastening member (7) associated with the nose-piece (6) and a second fastening member (8) which can be drawn together to abut the first annular body (3) and the second annular body (5), in such a way that the legs (4) of the first annular body (3) are inserted into the duct wall (2a) and are guided by the second annular duct (5) the applicator (100) comprises an arm (9) having one end shaped in such a way as to support the nose-piece (6) positioned perpendicularly to a transversal axis (Y) of extension of the arm (9), and the second fastening member (8) is movable along the transversal direction (Y) between a retracted position of non-interference with the end zone (2) of the duct, and an extracted position where it is aligned with the nose-piece (6).
