The invention relates to compositions of macromolecule nanometer biomedical substances and its manufacturing method. The compositions of macromolecule nanometer biomedical substances comprises at least nanometer particles of polysaccharide and vulcanization amino acid plated on the surface of the polysaccharide nanometer particles, or spread evenly inside or outside of the polysaccharide nanometer particles. The combination of macromolecule nanometer biomedical substance of this invention can be manufactured and prepared simply, and capable of promoting the production of collagen, preventing the cell from being destroyed by radicals, and can penetrate the human skin pore easily and release slowly, and it is easy to be absorbed and used for human body.本發明係一種高分子奈米生醫組合物及其製備方法，該高分子奈米生醫組合物至少包括有多醣類奈米顆粒及鍍覆於該多醣類奈米顆粒表面或均勻分佈於該多醣奈米顆粒內外的硫化氨基酸，本發明之高分子奈米生醫組合物製備簡單，並且具有促進膠原蛋白增生、預防自由基對細胞的破壞、可以輕易通透人體皮膚毛細孔並能緩效釋放之特色，容易為人體吸收利用。
