ЮДИН, Сергей Михайлович;YUDIN;ЕСКИ; Sergej Mikhajlovich;SOVETKIN, Stanislav Vasil'evich;ESKIN, Gennadij Vladimirovich;СОВЕТКИН, Станислав Васильевич;YUDIN, Sergej Mikhajlovich;YUDIN, Vladimir Sergeevich;ЮДИН, Владимир Сергеевич
发明人:
YUDIN, Sergej Mikhajlovich,ЮДИН, Сергей Михайлович,YUDIN, Vladimir Sergeevich,ЮДИН, Владимир Сергеевич,SOVETKIN, Stanislav Vasil'evich,СОВЕТКИН, Станислав Васильевич,ESKIN, Gennadij Vladimirovich,ЕСКИ,SOVETKIN, Stanislav Vasilevich,ЕСКИН
申请号：
RURU2012/000912
公开号：
WO2013/184024A1
申请日:
2012.11.08
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
The invention relates to veterinary science. The aim of the invention consists in using a chimeric somatostatin-containing protein for increasing sperm production in stud livestock and roosters in the form of a preparation for injection with low adjuvant reactogenicity, thus making it possible to administer injections without causing discomfort to stud livestock and roosters. The preparation for increasing sperm production in stud livestock and roosters is in the form of a suspension of a chimeric protein with water-insoluble enzyme-inactive chloramphenicol acetyltransferase without 10 C-terminal amino acids, an amino acid spacer (Sp) n, where n = 1, 2, 4, and 8, and somatostatin-14 having the amino acid sequence AGCFWKTFTSC in refined vegetable oil with an addition of beeswax. The method for increasing sperm production in stud livestock and roosters involves two subcutaneous injections, 14 days apart, of a preparation in the form of a suspension of a chimeric protein with water-insoluble enzyme-inactive chloramphenicol acetyltransferase without 10 C-terminal amino acids, an amino acid spacer (Sp) n, where n = 1, 2, 4, and 8, and somatostatin-14 having the amino acid sequence AGCFWKTFTSC in refined vegetable oil with an addition of beeswax, administered to roosters or livestock, upon reaching physiological maturity, in the amount of 50-200 micrograms of protein per 1 kilogram of body weight.L'invention se rapporte au domaine de la médecine vétérinaire et concerne l'utilisation de protéines chimériques contenant de la somatostatine afin d'accroître la production de sperme chez les éleveurs d'animaux de ferme et de coqs sous forme d'une préparation à injecter avec une faible capacité réactogène de l'adjuvant et permettant d'effectuer une injection sans sentiment de malaise pour les éleveurs d'animaux de ferme et de coqs. Cette préparation permettant d'augmenter la production de sperme chez les éleveurs de d'animaux de ferme et de coqs se présente sous forme d'une susp
