Nicholas C. Nicolaides,Luigi Grasso,Philip M. Sass
申请号：
US13356724
公开号：
US20120171200A1
申请日:
2012.01.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies methods of detecting cancer cells and methods of treating cancer using the antibodies.
