Endoscope sheath includes: (a) proximal end, (b) with the distal end in distal end region, (c) extend and connect the surface of the proximal end and the distal end between the proximal end and the distal end, (d) the multiple positioning devices positioned along the surface And (e) one or more drops keep features Wherein the sheath is configured to: (i) accommodates all or part of of endoscope and (ii) provides conduit, and the conduit is used to transmit fluid between the proximal end of the endoscope sheath and the distal end of the endoscope sheath when the endoscope is inserted into inside the sheath And wherein the multiple positioning device is positioned in the distal end region at the distal end of the endoscope sheath, so that the endoscope is fixed in the endoscope sheath And wherein one or more of drops keep features to be configured to generate the region limited by the endoscope sheath and the endoscope by the liquid of capillarity holding certain volume.
