The present disclosure is directed to barriers for use with anesthesia machines. In certain aspects, the present disclosure provides unique medical devices, systems, and methods that can effectively provide a clean touch surface on medical equipment without inhibiting function of the medical equipment. In accordance with certain embodiments, such medical devices are configured as barriers adapted for placement over a portion of an anesthesia machine. Accordingly, in one embodiment the present disclosure demonstrates a system for providing clean touch surfaces on anesthesia equipment, the system including: one or more touchscreen barriers configured to securely adhere to and substantially cover the touchscreen of an anesthesia machine, and one or more control member barriers configured to securely adhere to and substantially cover a control member portion of an anesthesia machine.