INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY
发明人:
KIM, UH HYUN,김우현,NAM, TAE SIK,남태식,PARK, KWANG HYUN,박광현,KIM, BYUNG JU,김병주
申请号:
KR1020120116718
公开号:
KR1020130044183A
申请日:
2012.10.19
申请国别(地区):
KR
年份:
2013
代理人:
摘要:
PURPOSE: A composition for prevention and treatment of diabetes including a NAD glycohydrolase inhibitor as an active ingredient is provided to be used as a cure for diabetes, especially type 2 diabetes, by accelerating hypoglycemic and insulin secretion.CONSTITUTION: A composition for prevention and treatment of diabetes comprises a development inhibitor or an activity inhibitor of NADase as an active ingredient. A NADase is originated from a mammal. The NADase is encoded as a base sequence of sequence number 1 or 2. Diabetes is type 2 diabetes. The active inhibitor is any one selected from a group comprised of antisense nucleotide, siRNA(short interfering RNA), and shRNA(short hairpin RNA) for complementarily uniting to mRNA of a NADase gene.COPYRIGHT KIPO 2013본 발명은 엔에이디 글리코하이드롤라제 (NAD glycohydrolase, NADase) 억제제를 유효성분으로 포함하는 당뇨병의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 엔에이디 글리코하이드롤라제 (NADase) 억제제는 혈당 저하 및 인슐린 분비를 촉진시키는 효과가 있어, 당뇨병, 특히 제2형 당뇨병 치료제로 유용하게 이용될 수 있다.