RIJCKEN CRISTIANNE JOHANNA FERDINAND,KRUIJTZER JOHANNES ANNA WILHELMUS,VAN NOSTRUM CORNELIS FRANCISCUS,VAN DER WAL STEFFEN,HENNINK WILHELMUS EVERHARDUS,LISKAMP ROBERTUS MATTHIAS JOSEPH,ALTINTAS ISIL
申请号：
IN2159/CHENP/2013
公开号：
IN2013CN02159A
申请日:
2013.03.18
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a particular class of biodegradable linkers ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS) such as DDS based on polymeric micelles or hydrogels. In addition the present invention relates to compounds comprising said linkers such compounds preferably being prodrugs. Further the invention is directed to the use of said linkers and especially said biodegradable linkers in a drug delivery system. Moreover the invention relates to controlled release system comprising a polymer matrix capable of releasing an active ingredient wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers as well as to a method of synthesising these linkers and preparing such controlled release systems.
