Christian Hubschwerlen,Jean-Luc Specklin,Paul Hebeisen
申请号：
BR9911178
公开号：
BRPI9911178B8
申请日:
1999.06.07
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"3- (2-oxo- [1,3 '] bipyrrolidinyl-3-ylidenemethyl) -febs derivatives" <；d>；. The present invention relates to novel compounds of formula (I) wherein R 14 is hydrogen, C 1-6 alkyl, optionally substituted by fluorine, or C 3-6 cycloalkyl； R 2 is hydrogen or a group selected from -ch ~ 2-c (= chr) -coor, -ch ~ 2-ocor, -ch (r) ocor, -ch (r) ocoor, -ch (ocor) ocor, -cr 2 -coch-2-ocor and (ii)； R ^ 3 ^ is hydrogen or group selected from -ch ~ 2 ~ c (= ch ~ 2 ~) -coor, -cooch ~ 2 ~ c (= chr) -coor, -cooch ~ 2-ocor, -cooch (r ) ocor, -cooch (r) ocoor, -cooch (ocor) ocor, -cooch-2-coch-2-ocor, and (iii)； provided that one of r ^ 2 ^ and r ^ 3 ^ is hydrogen and the other of r ^ 2 ^ and r ^ 3 ^ is different from hydrogen, r is hydrogen or C 1-6 -alkyl； R4 is hydrogen or hydroxy； R5 is hydrogen or hydroxyalkyl； ex is ch or n, as well as to pharmaceutically acceptable salts of said compounds and hydrates of said compounds and their salts, and to the use of compounds of formula (i) and pharmaceutically acceptable salts of said compounds and hydrates of said compounds and salts thereof for the manufacture of pharmaceutical preparations containing such compounds.patente de invenção:<；b>；"derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems"<；d>；. a presente invenção refere-se a novos compostos de fórmula (i) em que r^ 1^ é hidrogênio, c~ 1-6~-alquila, opcionalmente substituída por flúor, ou c~ 3-6~-cicloalquila； r^ 2^ é hidrogênio ou um grupo selecionado de -ch~ 2~c(=chr)-coor, -ch~ 2~ocor, -ch(r)ocor, -ch(r)ocoor, -ch(ocor)ocor, -cr~ 2~coch~ 2~ocor e (ii)； r^ 3^ é hidrogênio ou grupo selecionado de -ch~ 2~c(=ch~ 2~)-coor, -cooch~ 2~c(=chr)-coor, -cooch~ 2~ocor, -cooch(r)ocor, -cooch(r)ocoor, -cooch(ocor)ocor, -cooch~ 2~coch~ 2~ocor, e (iii)； com a condição de que um de r^ 2^ e r^ 3^ seja hidrogênio e o outro de r^ 2^ e r^ 3^ seja diferente de hidrogênio, r é hidrogênio ou c~ 1-6~-alquila； r^ 4^ é hidrogênio ou hidróxi, r^ 5^é hidrogênio ou <；sym>；-hid
