Fan Wu;David Byers;Donald Weaver;Annette Henneberry;Christopher McMaster;Fuqiang Ban;Chris Barden
发明人:
Fan Wu,Donald Weaver,Chris Barden,Christopher McMaster,David Byers,Annette Henneberry,Fuqiang Ban
申请号：
US11909636
公开号：
US08835476B2
申请日:
2006.03.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.
