The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.Linvention concerne un dispositif dadministration transdermique non invasive généralement associé à un appareil mécanique portatif dadministration transdermique non invasive dun gaz, dagents pharmaceutiques petits ou grands solubles dans leau (hydrophiles), de vitamines, ou dautres agents thérapeutiques. Elle concerne également des composants de ces dispositifs dadministration, des procédés de production dune substance comprenant une quantité sursaturée dun gaz dissous, ainsi que des méthodes dadministration dun agent thérapeutique ou de traitement dune maladie ou dune affection au moyen des dispositifs dadministration de linvention.
