TG Therapeutics, Inc.;Rhizen Pharmaceuticals SA;Laboratoire Francais du Fractionnement et des Biotechnologies
发明人:
Michael S. Weiss,Hari P. Miskin,Peter Sportelli,Swaroop K.V.S. Vakkalanka
申请号：
US16946585
公开号：
US20200323981A1
申请日:
2020.06.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Highly effective combinations of a compound of formula A (a PI3Kδ selective inhibitor) and anti-CD20 antibodies are provided herein for the treatment and amelioration of PI3Kδ and/or CD20 mediated diseases and disorders. In particular, the combination can be used to treat cancers and autoimmune diseases. More particularly, the invention provides for a combination of a compound of formula A, or stereoisomers thereof, and ublituximab for the treatment and/or amerioration of hematological malignancies such as leukemia and lymphoma. The invention also provides for a combination of a compound of formula A, or stereoisomers thereof, and anti-CD20 antibodies, including ublituximab for the treatment and/or amelioration of multiple scelrosis.
