János Tibor Kodra,Patrick William Garibay,Thomas Hoeg-Jensen,Ib Jonassen,Peter Madsen,Tina Møller Tagmose
申请号：
US13273659
公开号：
US08476228B2
申请日:
2011.10.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain and possible linkers which link the individual components in the side chain together via amide bonds.
