SCHOETTLE, Isabell,HAGENDORF, Annika,FUERST, Christiane,HAUCK, Gerrit,SIEFKE-HENZLER, Verena,KAMM, Walter,SCHNIEDERS, Julia
申请号：
ES10730443
公开号：
ES2614161T3
申请日:
2010.07.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
An aqueous pharmaceutical formulation containing an insulin analog compound or an insulin derivative, or a pharmacologically tolerable salt thereof, and methionine, the pH value of the formulation being 4.5 or smaller and (I) being chosen the insulin-like compound between a group consisting of Gly (A21), Arg (B31), Arg (B32) -Human insulin, Lys (B3), Glu (B29) -Human insulin, Asp (B28) -Human insulin, Lys (B28) Pro (B29) -Human insulin, Des (B30) -Human insulin and an insulin-like compound of Formula I, ** Formula ** corresponding A0 to Lys or Arg； A5 to Asp, Gln or Glu； A15 to Asp, Glu or Gln； A18 to Asp, Glu or Asn； B-1 to Asp, Glu or an amino group； B0 to Asp, Glu or to a chemical bond B1 to Asp, Glu or Phe； B2 to Asp, Glu or Val； B3 to Asp, Glu or Asn； B4 to Asp, Glu or Gln； B29 to Lys or to a chemical bond B30 to Thr or to a chemical bond B31 to Arg, Lys or to a chemical bond B32 to Arg-Amida, Lys-Amida or to an amino group corresponding to two amino acid radicals of the set consisting of A5, A15 , A18, B-1, B0, B1, B2, B3 and B4, simultaneously and independently of each other, to Asp or Glu, and the particular insulin analog compound being chosen in particular from a set consisting of: Arg (A0), His (A8), Glu (A5), Asp (A18), Gly (A21), Arg (B31), Arg (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu ( A5), Asp (A18), Gly (A21), Arg (B31), Lys (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu (A15), Asp (A18), Gly (A21 ), Arg (B31), Arg (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu (A15), Asp (A18), Gly (A21), Arg (B31), Lys (B32) -NH2 Human Insulin, Arg (A0), His (A8), Glu (A5), Glu (A15), Gly (A21), Arg (B31), Arg (B32) -NH2 Human Insulin, Arg (A0), His (A8), Glu (A5), Glu (A15), Gly (A21), Arg (B31), Lys (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu (A5), Gly (A21), Asp (B3), Arg (B31), Arg (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu (A5), Gly (A21), Asp (B3), Arg (B31), Lys (B32) -NH2 Human insulin, Arg (A0), His (A8), Glu (A15), Gly (A21), A
