The purpose of the present invention is to provide a freeze-dried preparation having improved hepatocyte growth factor storage stability in comparison to conventional freeze-dried preparations. The present invention provides a freeze-dried preparation containing (1) hepatocyte growth factor, (2) trehalose, and (3) one or more compounds selected from the group consisting of arginine, histidine, lysine, meglumine, glutamic acid, aspartic acid, proline, creatine, creatinine, trishydroxymethylaminomethane, and pharmacologically acceptable salts of these.本發明目標在於提供一冷凍乾燥製劑，該冷凍乾燥製劑相較于傳統冷凍乾燥製劑具有改進的肝細胞增生因子儲存穩定性。本發明提供一冷凍乾燥製劑，該冷凍乾燥製劑包括(1)一肝細胞增生因子，(2)海藻糖以及(3)一種或多種選自由以下各項組成的群組之化合物：精胺酸、組胺酸、離胺酸、葡甲胺、穀胺酸、天冬胺酸、脯胺酸、肌酸、肌酸酐、三羥甲基胺基甲烷、及其藥學上容許之鹽。
