PROBLEM TO BE SOLVED: To provide a technical means for producing preparation in which leachability of salt of medicine whose periphery is in a surrounded state by enteric polymer is significantly improved.SOLUTION: There is provided solid preparation or the like that contains a composition containing salt of medicine whose periphery of is coated by enteric polymer, and furthermore a non-enteric polymer is contained in the coating composition. It is preferable that the enteric polymer is methacrylic acid copolymer or the like, it is preferable that the non-enteric polymer is water-insoluble polymer such as ethyl acrylate/methyl methacrylate copolymer, and it is preferable that salt of the medicine is Duloxetine hydrochloride.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】腸溶性高分子によって周囲が囲まれた状態にある薬物の塩の溶出性が有意に改善された製剤を製造するための技術的手段を提供すること。【解決手段】薬物の塩を含む組成物の周囲が腸溶性高分子で被覆されたものを含有し、更に非腸溶性高分子が当該被覆組成物中に含まれる、固形製剤等を提供する。当該腸溶性高分子はメタクリル酸コポリマー等であることが望ましく、当該非腸溶性高分子はアクリル酸エチル・メタクリル酸メチルコポリマー等の水不溶性高分子であることが望ましく、当該薬物の塩はデュロキセチン塩酸塩であることが望ましい。【選択図】なし
