Destruction of tumor cells by trifunctional bispecific antibodies with low to medium expression levels of tumor-associated target antigens

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专利权人:

Horst Lindhofer

发明人:

Horst Lindhofer

申请号：

US12224010

公开号：

US09017676B2

申请日:

2007.02.15

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases is provided. Trifunctional bispecific antibodies bind to tumor-associated antigens including Her2/neu, CD20, EpCAM, G250, proteoglycans, GD3. GD2, MHC II, EGF-R and CEA expressed on tumor cells at low to medium expression levels. Also provided are methods for the treatment or prophylaxis of tumor diseases by administering a pharmaceutically effective amount of a trifunctional bispecific antibody to a patient in need thereof.

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