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COMBINATION THERAPIES WITH RECOMBINANT LISTERIA STRAINS
专利权人:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;ADVAXIS, INC.
发明人:
PETIT, Robert,WALLECHA, Anu,PATERSON, Yvonne,SINGH, Reshma
申请号:
SG11201704662S
公开号:
SG11201704662SA
申请日:
2015.12.18
申请国别(地区):
SG
年份:
2017
代理人:
摘要:
Disclosed herein are compositions comprising use of compositions comprising a live attenuated recombinant Listeria strain comprising a fusion protein of a truncated listeriolysin O (LLO) protein, a truncated ActA protein, or a PEST amino acid sequence fused to a heterologous antigen, including a tumor-associated antigen, wherein the compositions further comprise or are co-administered with an antibody or fragment thereof. Also disclosed are combination therapies comprising use of these compositions comprising live attenuated recombinant Listeria strains, in conjunction with an antibody or fragment thereof for use in treating, protecting against, and/or inducing an immune response against a tumor, especially wherein the treating, protection against and/or inducing an immune response increases percent survival in a subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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