AMÉLIORATIONS DE PROCÉDÉS DE CULTURE D'OLIGODENDROCYTES ET DE MÉTHODES DE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS À L'AIDE D'HORMONES THYROÏDIENNES OU ANALOGUES
PETRATOS, Steven,AZARI, Michael, Farzad,LEE, Jae, Young,KIM, Min, Young
申请号：
EP15871340
公开号：
EP3237605A4
申请日:
2015.12.24
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to methods of treating or ameliorating certain neurodegenerative disorders (namely, dysmyelinating and demyelinating disorders) in patients in need of such treatment or amelioration. The invention provides methods of treating or ameliorating a patient in need of such treatment and includes the administration to the patient of: (a) thyroid hormones or thyroid hormone analogues； (b) cell replacement therapies involving the use of homogenous Oligodendrocyte Precursor Cells derived from embryonic stem cells that have been treated with thyroid hormones or thyroid hormone analogues； (c) gene therapy to correct mutated genes in vivo； or (d) a combination of two or more of (a), (b) and (c). The invention also provides compositions and formulations of thyroid hormones and thyroid hormone analogues for use in treating or ameliorating such disorders.
