MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE; INC.
发明人:
MELLOR, ANDREW,MUNN, DAVID
申请号：
CA2483451
公开号：
CA2483451C
申请日:
2002.04.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention is based on the discovery antigen-presenting cells(APCs) may be generated to have predetermined levels of expression of theintracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression ofhigh levels of IDO is correlated with a reduced ability to stimulate T cellresponses and an enhanced ability to induce immunologic tolerance, APCs havinghigh levels of IDO may be used to increase tolerance in the immune system, asfor example in transplant therapy or treatment of autoimmune disorders. Forexample, APCs having high levels of IDO, and expressing or loaded with atleast one antigen from a donor tissue may be used to increase tolerance of therecipient to the donors tissue. Alternatively, APCs having reduced levels ofIDO expression and expressing or loaded with at least one antigen from acancer or infectious pathogen may be used as vaccines to promote T cellresponses and increase immunity.
