dba San Diego State University Research Foundation;San Diego State University (SDSU) Foundation
发明人:
Mark Alan SUSSMAN
申请号：
US16488464
公开号：
US20200190475A1
申请日:
2018.02.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are methods for identifying and isolating cardiac stem or cardiac progenitor cells, and methods for making and using them, including comprising identifying cells expressing the Lin28 polypeptide, cells that are Lin28+； cells that are Lin28+ can be isolated using polypeptides or antibodies that can specifically or non-specifically bind Lin28. Provided are methods for inducing or accelerating cardiogenesis in the mammalian heart, or for treating a heart genetic defect, injury or dysfunction, or an injury or dysfunction subsequent to an ischemic injury or a heart failure, or an injury or dysfunction resulting from a myocardial infarction, comprising administering to an individual one or more of the Lin28+ cardiac stem cells or cardiac progenitor cells, including Lin28+ cardiac stem cells or cardiac progenitor cells isolated by a method as provided herein, or a Lin28+ interstitial population provided herein, or administrating to a patient a product of manufacture provided herein.
