UTILISATION D'ANTICORPS POUR L'ENRICHISSEMENT DE LYMPHOCYTES T GENETIQUEMENT MODIFIES AVEC DES RECEPTEURS IMMUNITAIRES EXOGENES ET ANTICORPS POUR UNE UTILISATION DANS LA DEPLETION DES LYMPHOCYTES T GENETIQUEMENT MODIFIES

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专利权人:

UMC UTRECHT HOLDING B.V.

发明人:

KUBALL, JURGEN HERBERT ERNST

申请号：

CA2968457

公开号：

CA2968457A1

申请日:

2015.11.20

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The current invention now provides for exogenous immune receptors that do not require any additional selection marker genes and/or any additional suicide genes. The invention now allows for the production of engineered T cells that can be enriched for in an untouched manner, i.e. the engineered T cells do not require any interaction with any outside agent and can selected for by eliminating T cells that express the endogenous alpha beta T cell receptor. Engineered T cells with an exogenous immune receptor are provided that can be differentiated from endogenous T cell receptor and now can be eliminated, i.e. depleted, with a selective antibody that specifically targets the exogenous immune receptor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/