The invention provides a system and method for pain treatment in which a medication is delivered with good localization to the SPG and to the maxillary division of the trigeminal nerve—known a V2. A treating physician uses a drug delivery device to insert a delivery catheter into nostril of a patient lying supine and orient the catheter with respect to the SPG and V2. The physician operates a mechanism on the catheter to express the medication and allows for gravity-influenced transport to bring the medication to the SPG and V2.
