Device for connecting a tubular part having a first end provided with a tip, and a second end provided with a connecting device. The connecting device connects an inside of the tubular part with a syringe and with the inside of a bottle, which bottle includes a neck having a stopper penetrable by the tip of the tubular part. Device includes a supporting device for sealing and fitting the device into place on the neck of the bottle in a tight and substantially centered manner. A holding device holds the tubular part in a displaceable manner relative to the supporting device in a penetration direction of the tip of the tubular part. Holding device includes a tight, deformable membrane with two edges, one edge of which is connected tightly to the tubular part and another edge of which is connected tightly to the supporting device.