A portable CT scanner may include a rotatable frame with separable portions. An x-ray source may be coupled to one portion of the rotatable frame, and an x-ray detector may be coupled to another portion of the rotatable frame. During storage and transportation, one portion of the rotatable frame may be housed in a first enclosure, and another portion of the rotatable frame may be housed in a second enclosure. When operation of the scanner is desired, the two enclosures may be connected, and/or the rotatable frame portions may be connected with the enclosures abutting one another, to allow for rotation of the rotatable frame about an aperture formed by the enclosures.