INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 December 2018 (13.12.2018) WIPO I PCT oimitia °nolo III01110111IIIIIIIIII010m 1111101 ois (10) International Publication Number WO 2018/226667 Al (51) International Patent Classification: A61M 1/00 (2006.01) A61F 13/02 (2006.01) A61F 13/00 (2006.01) (21) International Application Number: PCT/US2018/036019 (22) International Filing Date: 05 June 2018 (05.06.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/516,566 07 June 2017 (07.06.2017) US 62/516,550 07 June 2017 (07.06.2017) US 62/516,540 07 June 2017 (07.06.2017) US 62/565,754 29 September 2017 (29.09.2017) US 62/576,498 24 October 2017 (24.10.2017) US 62/592,950 30 November 2017 (30.11.2017) US 62/613,494 04 January 2018 (04.01.2018) US 62/615,821 10 January 2018 (10.01.2018) US 62/616,244 11 January 2018 (11.01.2018) US 62/623,325 29 January 2018 (29.01.2018) US 62/625,704 02 February 2018 (02.02.2018) US (71) Applicant: KCI LICENSING, INC. [US/US]； P.O. Box 659508, San Antonio, TX 78265-9508 (US). (72) Inventors: LOCKE, Christopher, Brian； 6 Bosworth Mews, Bournemouth BH9 3SD (GB). ROBINSON, Tim- othy, Mark； 19 Wessex Avenue, Shillingstone DT11 OTG (GB). (74) Agent: WELCH, Gerald, T. et al.； Harness, Dickey & Pierce, P.l.c., 5445 Corporate Drive, Suite 200, Troy, MI 48098 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV,
