THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
STEVENS, DAVID MICHAEL,STERN, STEPHAN TIMOTHY,MCNEIL, SCOTT,DOBROVOLSKAIA, MARINA A.
申请号：
CA3079121
公开号：
CA3079121A1
申请日:
2018.10.15
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention is directed to a polymer platform comprising poly(L-lysine succinylated) which specifically targets scavenger receptor A1. This platform may be used to conjugate different types of drugs to the polymer for treatment of specific diseases or conditions in a patient. The resulting conjugates display moderate stability or controlled drug release of about 3-80 hours in plasma, and allow delivery and release of drugs and other therapeutic moieties to tissues/cells that express scavenger receptor A1 in a controlled manner.
