YAO, Xiao-Jun,LEUNG, Lai-Han Elaine,LUO, Lian Xiang,LIU, Liang
申请号：
AU2018101501
公开号：
AU2018101501A4
申请日:
2018.10.10
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018101501A420181108.pdf#####ABSTRACT The present invention relates to the administration of a compound of formula (1) advantageous efficacious as PDE6 inhibitor and its effects on subjects with cancer. More specifically, the present invention is directed to a method for administering a compound having favorable geometric properties for interacting with the PDE6 prenyl-binding pocket for treating a subject suffering from cancer, in particular lung cancer. The structural components contribute an advantageous interaction with PDE6, in particular with amino acids in the binding pocket. The present invention further provides a method of inhibiting the growth or proliferation of cancer cells as well as pharmaceutical compositions comprising said compound.IL -L CY) KA r b) U-
